Well, the experts aren't responding much so you'll get my opinion...
Don't think it will be a prob, assuming you are using a mast support up front.
The Bob will add to the bounce though. I like the single mast cradle and it is convenient. Usually trailer with mast apart, with the upper part with Bob bungeed to the lower mast section that is in the cradle.
I am a lazy fool who doesn't like to have to think, so if on a long trip when I wouldn't want to have to worry about bouncing Bob, I would probably remove it since it's just screws. Long trip = > 150 miles.